The day you remove the CIDR, you also give the goat an injection of PG 600 (also natural hormones - -this mixture will help cause ovulation and is sold for that purpose for maiden pigs). Dinoprost tromethamine was administered to adult mares (weighing 320 to 485 kg; 2 to 20 yearsold), at the rates of 0, 100, 200, 400, and 800 mg per mare per day for 8 days. Do not administer to pregnant cattle, unless abortion is desired. An interesting observation in the above study was that the radioactive dose of 3H PGF2 alpha rapidly distributed in tissues and dissipated in tissues with almost the same curve as it did in the serum. Sweating was temporary in all cases and was mild for doses of 3.0 mg or less but was extensive (beads of sweat over the entire body and dripping) for the 10 mg dose. In this post we leave you some practical advice published in pig 333 to induce heat in gilts and sows that you can carry out in your centers. Luteolytic doses of dinoprost tromethamine are on the order of 5 to 10mg administered on one day, therefore, LUTALYSE Injection was demonstrated to have a wide margin of safety. PG 600 comes as a fluid and a powder, and you have to use a needle and syringe to mix the two before use. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers. Data suggest prostaglandins, especially PGEs and PGFs, may be involved in the process of ovulation and gamete transport. 3. P.G. Neither heart rate nor respiration rates were significantly altered (P> 0.05) when compared to contemporary control values. Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection. Cattle expressing estrus following LUTALYSE Injection are receptive to breeding by a bull. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract. JavaScript seems to be disabled in your browser. For Difficult-to-Breed Mares: In one study with 122 Standardbred and Thoroughbred mares in clinical anestrus for an average of 58 days and treated during the breeding season, behavioral estrus was detected in 81 percent at an average time of 3.7 days after injection with 5mg LUTALYSE Injection; ovulation occurred an average of 7.0 days after treatment. Dinoprost was non-teratogenic in the rabbit when administered either subcutaneously at doses of 0.5 and 1.0 mg dinoprost/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14 or 15, 16 and 17 or orally at doses of 0.01, 0.1 and 1.0 mg dinoprost/kg/day on days 6-18 or 5.0 mg/kg/day on days 8-18 of gestation. Cattle: Limited salivation has been reported in some instances. Thus, the 100 mg dose gave a safety margin of 10 to 20X for a single injection or 80 to 160X for the 8 daily injections. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. Mares: 1. LUTALYSE HighCon Injection is for use with FACTREL Injection (gonadorelin injection) to synchronize estrous cycles to allow for fixed-time artificial insemination (FTAI) in lactating dairy or beef cows. It works fine to give once- about 2/3 of your cycling cows will come into heat. Due any day now. zoetis Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. Dinoprost was non-teratogenic in the rabbit when administered either subcutaneously at doses of 0.5 and 1.0 mg dinoprost/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14 or 15, 16 and 17 or orally at doses of 0.01, 0.1 and 1.0 mg dinoprost/ kg/day on days 6-18 or 5.0 mg/kg/day on days 8-18 of gestation. Although quantitative differences were observed, qualitatively similar metabolites were produced. At that point, the mare should come into heat. No apparent differences were observed between the intramuscular and subcutaneous routes of administration. Mares usually continue to eat during the period of expression of side effects. For Treatment of Pyometra (chronic endometritis) in Cattle: In studies conducted with LUTALYSE Injection, pyometra was defined as presence of a corpus luteum in the ovary and uterine horns containing fluid but not a conceptus based on palpation per rectum. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. For Estrus Synchronization in Beef Cows, Beef Heifers and Replacement Dairy Heifers. Treatment of anestrous mares which abort subsequent to 36days of pregnancy may not result in return to estrus due to presence of functional endometrial cups. Mares: The most frequently observed side effects are sweating and decreased rectal temperature. Whether or not it is fertile is another story. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Rectal temperature was decreased during the interval 0.5 until 1.0, 3 to 4, or 5 hours after injection for 0.25 and 1.0 mg, 2.5 and 3.0, or 5.0 and 10.0 mg dose groups, respectively. Lutalyse won't bring an anestrus cow into heat, it will only induce it in cows that are already cycling. For Treatment of Pyometra (chronic endometritis) in Cattle. Physical exposure using an intact or vasectomized boar provides the full range of stimuli. For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers: Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday). Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Use contents within 12 weeks of first vial puncture. The statistical predicted relative abortion rate based on the dose titration data, was about 93% for the 5 mL (25mg) LUTALYSE Injection dose for cattle injected up to 100 days of gestation. Inject a dose of 25 mg intramuscularly. 3. What is Lutalyse? Look for signs of labor to start at 20 to 26 hours after the induction injection. 4. Veterinarians are often asked to induce parturition or they may recommend induction based on the mare's foaling history or the presence of medical conditions that threaten her health and well being. The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). Treatment of anestrous mares which abort subsequent to 36 days of pregnancy may not result in return to estrus due to presence of functional endometrial cups. For Treatment of Pyometra (chronic endometritis) in Cattle. LUTALYSE Injection is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing. Cattle: LUTALYSE Sterile Solution is supplied at a concentration of 5 mg dinoprost per mL. Use to induce parturition after day 270. The species which exhibit a single estrus cycle are known as monstrous and species which come into estrus twice or more are termed polyestrous animals. Accidental spillage on the skin should be washed off immediately with soap and water. I believe the dose is 1 1/2 cc for a doe. How does Lutalyse work? No mortality occurred in any of the groups. A slight and marked embryo lethal effect was observed in dams given 1.0 and 5.0 mg dinoprost/kg/ day respectively. Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection. This information is essential to determine the appropriate time for administration of LUTALYSE Injection. after injection. Additional studies investigated the effects in the mare of single intramuscular doses of 0, 0.25, 1.0, 2.5, 3.0, 5.0, and 10.0 mg dinoprost tromethamine. Store at controlled room temperature 20 to 25C (68 to 77F). Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. These effects are usually seen within 15 minutes of injection and disappear within one hour. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers: Commercial cattle were palpated per rectum for pregnancy in six feedlots. Store at controlled room temperature 20 to 25C (68 to 77F). Controlling Time of Estrus of Estrous Cycling Mares: Mares treated with LUTALYSE Injection during diestrus (4 or more days after ovulation) will return to estrus within 2 to 4days in most cases and ovulate 8 to 12 days after treatment. Difficult-to-Breed Mares: In extended diestrus there is failure to exhibit regular estrous cycles which is different from true anestrus. The metabolism of tritium labeled dinoprost (3H PGF2 alpha) in the rat and in the monkey was similar. Hormonal injection in prepubertal gilts and sows with a combination of eCG and hCG induces rapid follicle growth and estrus in 4 to 5 days. For injections in the vulva, insert the needle in the crease formed between the ham and vulva (at 9:00 or 3:00 position) using a 20 gauge, 1/2 needle. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. 1. Unless you have her in with a bull so she might get bred without you knowing it, if you haven't seen any heat before then, repeat the lutalyse injection in about 2 weeks or use some other program. For a copy of the Safety Data Sheet or to report adverse reactions, call Zoetis Inc. at 1-888-963-8471. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. Individual animals respond differently to treatment. After 14days, recovery rate of treated cattle was no different than that of non-treated cattle. Products for Farrowing and Breeding Swine, Swine Ear Tags, Marking, & Identification Products, Skip to the beginning of the images gallery. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid. This website uses cookies to improve your experience while you navigate through the website. Be watchful of normal signs of labor. Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection. The most common drug used in dogs to induce heat is PG 600, a combination of 400 IU of Pregnant Mare Serum Gonadotrophin and 200 IU of Human Chorionic Gonadotrophin originally formulated for use in swine. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. This luteolytic effect can be utilized to control the timing of estrus in estrous cycling and clinically anestrous mares that have a corpus luteum in the following circumstances: 1. Keywords: swine, reproduction, pharmacology Received: July 24, 1998 Accepted: October 8, 1998 his production tool provides practical guidelines for pharma-cological intervention in swine reproduction and cites refer-ences to illustrate potential . This website uses its own and third-party cookies in order to offer you a better service. Care should be taken to avoid injection through wet or dirty areas of skin. Induction of abortion in feedlot cattle at stages of gestation up to 100 days of gestation did not result in dystocia, retained placenta or death of heifers in the field studies. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. 2. Mares did not appear to sustain adverse effects following termination of the side effects. One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed. CV (Allows files .doc, .pdf and .odt up to 3MB). 5 mg dinoprost/mL as dinoprost tromethamine. Return to normal was defined as evacuation of fluid and return of the uterine horn size to 40mm or less based on palpation per rectum at 14 and 28 days. This procedure may be utilized as an aid to scheduling the use of stallions. However, induction of parturition or abortion with any exogenous compound may precipitate dystocia, fetal death, retained placenta and/or metritis, especially at latter stages of gestation. After 14 days, recovery rate of treated cattle was no different than that of non-treated cattle. ESTRUMATE is a prostaglandin analogue that causes regression of the corpus luteum, which results in estrus in two to five days in cycling animals. A 14-day continuous intravenous infusion study in rats at 20 mg PGF2 per kg body weight indicated prostaglandins of the F series could induce bone deposition. There was no evidence of toxicological effects. LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Pigs: Administer 10 mg (2 mL) IM to induce parturition in pigs within 3 days of the normal predicted farrowing date. Evaluate the reproductive status of the mare. Lutalyse Injectable is used in cattle for estrus synchronization, treatment of uterine infections, and induction of abortion; in swine for induction of parturition and in horses f But opting out of some of these cookies may have an effect on your browsing experience. This information is essential to determine the appropriate time for administration of LUTALYSE Injection. 4.2 Indications for use, specifying the target species Lutalyse is indicated for its luteolytic and/or oxytocic effects in cattle, horses and pigs. Managers using prostaglandins in this manner must use caution. Who is Lutalyse for? Approved by FDA under NADA # 108-901 User Safety: Not for human use. Prostaglandins, especially PGF2, have been shown to 1) increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis, 2) be capable of crossing from the uterine vein to the ovarian artery (sheep), 3) be related to IUD induced luteal regression (sheep), and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for Synchronization of Estrus in Lactating Dairy Cows: Administer one EAZI-BREED CIDR Cattle Insert per animal and remove 7 days later (for example if administered on a Monday remove the following Monday). How much lutalyse to give a goat. Cattle that abort will abort within 35 days of injection. Better luteolysis is related to better conception. Accidental spillage on the skin should be washed off immediately with soap and water. LUTALYSE Injection is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing. Necessary cookies are absolutely essential for the website to function properly. Induction is a procedure used to advance estrus. Following abortion, early fetal death and resorption, or as a result of pseudopregnancy, there may be serum progesterone levels consistent with a functional corpus luteum. There was no unequivocal effect of dinoprost on the hematology or clinical chemistry parameters measured. Estrus may be induced in diestrous mares (having a corpus luteum that is 5 or more days postovulation) by treatment with natural PGF 2 (10 mg, IM) or cloprostenol (250 mcg, IM) to lyse the corpus luteum. No preslaughter drug withdrawal period is required for labeled uses in swine. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Some of these factors are: a. 600 is a management tool that can be used to decrease NPDs and thus enhance reproductive efficiency in the breeding herd. These side effects are transitory, lasting from 10 minutes to 3hours, and were not detrimental to the health of the animal. Below are three examples of treatment regimens for FTAI that fit within the dosage regimen framework described immediately above: 2nd FACTREL + FTAI at 48 hours after LUTALYSE. For Intramuscular Use for Treatment of Pyometra (chronic endometritis) in Cattle. With lutalyse, I give 2cc. Inject a dose of 5mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. Induction of abortion in feedlot cattle at stages of gestation up to 100 days of gestation did not result in dystocia, retained placenta or death of heifers in the field studies. Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. Dinoprost is a natural prostaglandin. It is important that adequate records be maintained on (1) the average length of gestation period for the animals on a specific location, and (2) the breeding and projected farrowing dates for each animal. Swine: The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10x) dose only, possible vomiting. Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection. Why use Lutalyse? A complete study on the distribution of decline of 3H PGF2 alpha Tham in the tissue of rats was well correlated with the work done in the cow. LUTALYSE Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. 1. Mares treated with either 400 mg or 800 mg exhibited more profound symptoms. Breed cows as they are detected in estrus. LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. If estrus has not been observed by 80 hours after injection, breed at 80 hours. Mares should return to estrus in ~3 days and ovulate an average of 8-10 days after PGF 2 treatment. Product does require a PIPESTONE veterinarian prescription to purchase. Assuming you are referring to the drug lutalyse: How Much Estrumate Do You Give A Horse? 2. The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). The manipulation of the reproductive process reduces the need to detect estrus, creates a more uniform calf crop, and shortens the breeding and calving seasons. He says he likes the drug because it induces sows more calmly and predictably but Lutalyse is also a choice for inducing females. In male swine, as in other mammals, GnRH is secreted from the brain and binds to receptors on the anterior pituitary gland, ultimately causing the release of luteinizing hormone (LH). Metabolism: A number of metabolism studies have been done in laboratory animals. More specifically, dinoprost is used for: estrus synchronization, as well as the treatment of unobserved (silent) estrus, and pyometra (chronic endometritis) in cattle; abortion of . Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. CONTACT INFORMATION How much Lutalyse do I need to induce a sow? Research has shown that there is no adverse affects on the subsequent litter. The abortion rates following injection of LUTALYSE Injection increased with increasing doses up to about 25 mg. As examples, the abortion rates, over 7 feedlots on the dose titration study, were 22%, 50%, 71%, 90% and 78% for cattle up to 100 days of gestation when injected IM with LUTALYSE Injection doses of 0,1 (5 mg), 2 (10 mg), 4 (20 mg) and 8 (40 mg) mL, respectively. In turn, LH travels through the blood stream and causes the testicles to synthesize and secrete testosterone. Keep out of the reach of children. Mares: Dinoprost tromethamine was administered to adult mares (weighing 320 to 485 kg; 2 to 20 years old), at the rates of 0, 100, 200, 400, and 800 mg per mare per day for 8days. 2. There was no evidence of toxicological effects. days 5 and 50 of gestation, give 1-2 mLs (5-10 mg). Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract. 5 mg dinoprost/mL as dinoprost tromethamine. If she came into heat on. Usage Lutalyse is used to control estrus time in estrous-cycling mares. 7. How do you tell if a cow is in heat? Keep in mind that administration of these products is relatively effective in nearly every stage of pregnancy, so it is extremely important to know the exact breeding date of the females which you intend to induce . Cattle administered a progestin would be expected to have a reduced response to LUTALYSE Injection. A study demonstrated that equimolar doses of 3H PGF2 alpha Tham and 3H PGF2 alpha free acid administered intravenously to rats demonstrated no significant differences in blood concentration of dinoprost. Use only sterile needles, and use each needle only once. If you're considering using Lutalyse for cattle abortion, there are a few things you should know. Protect from freezing. of 2 mL LUTALYSE (10 mg dinoprost) to parturition of approximately 30 hours. These data support previous reports that dinoprost has a halflife of minutes. 6. Since Lute does not directly cause ovulation, a gonadotropin hormone may also be needed to resolve cysts and trigger ovulation. one of the most widely use d natural polysaccharides in the food, agriculture, textile, pol-. Zoetis Inc. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. Squires said many managers and veterinarian put mares under artificial light for 60 days before administering altrenogest for 10 to 14 days. Late gestation is a time of final maturation of the developing fetus. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. Lutalyse is indicated for estrus synchronization, treatment of unobserved (silent) estrus and pyometra (chronic endometritis) in cattle; for abortion of feedlot and other non-lactating cattle; for parturition induction in swine; and for controlling the timing of estrus in estrous cycling mares and clinically anestrous mares that have a corpus How do you induce heat in sows? Ltd. Prick the injection site with your finger two or three times before injecting the needle so as not to startle the sow and cause her to jump up. Also PGF2 has been reported to cause increase in blood pressure, bronchoconstriction, and smooth muscle stimulation in certain species. 3. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Lutalyse is the brand name for dinoprost tromethamine, a sterile solution used for several cattle, swine and mare birthing & birth-related medical conditions. LUTALYSESTERILE- dinoprost tromethamineinjection, solution Lutalyse is used to control the timing of estrus and ovulation in estrous cycling cattle that. Ad ai synchronization programs can improve breeding success. See the Terms of Use for further details. 5. Do not use oxytocin unless at least one pig has been born or continual supervision is practiced. For Treatment of Pyometra (chronic endometritis) in Cattle. Available for Android and iOS devices. Inject a dose of 25 mg dinoprost (5mL) intramuscularly. One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed. Cattle serum collected during 24 hours after doses of 0 to 250 mg dinoprost have been assayed by RIA for dinoprost and the 15-keto metabolites. Cattle must be ready to breedthey must have a corpus luteum and be healthy; b. Nutritional status must be adequate as this has a direct effect on conception and the initiation of estrus in heifers or return of estrous cycles in cowsfollowing calving; c. Physical facilities must be adequate to allow cattle handling without being detrimental to the animal; d. Estrus must be detected accurately if timed Al is not employed; A successful breeding program can employ LUTALYSE Injection effectively, but a poorly managed breeding program will continue to be poor when LUTALYSE Injection is employed unless other management deficiencies are remedied first. Residue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. When deciding if it appropriate to abort heifers, you should consider that the chance of complications greatly increases the farther pregnant the heifer is. In pigs, evaluation was made of clinical observations, food consumption, clinical pathologic determinations, body weight changes, urinalysis, organ weights, and gross and microscopic observations following treatment with single doses of 10, 30, 50 and 100 mg dinoprost administered intramuscularly. Lutalyse is an effective luteolytic agent for mares and cattle and is used to induce parturition in swine. In the early stages, women may be unaware of their pregnancies. Lutalyse contains a well characterized prostaglandin that occurs naturally in nearly all mammalian tissue. LUTALYSE is effective only in those cattle having a corpus luteum (i.e., those that ovulated at least five days prior to treatment). Dinoprost is a natural prostaglandin. Swine: LUTALYSE Sterile Solution will induce parturition in swine at 10 mg (2 mL) when injected intramuscularly. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval. On Day 5 inject all cows not bred. For abortion the result gets progressively less reliable after about day 75 of the pregnancy. Thus, dinoprost had a safety factor of at least 10X on injection (25 mg luteolytic dose vs. 250 mg safe dose), based on studies conducted with cattle. When do you give Lutalyse? LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Sweating was observed for 0 of 9, 2 of 9, 7 of 9, 9 of 9, and 8 of 9 mares injected with 0.25, 1.0, 2.5, 3.0, 5.0, or 10.0mg dinoprost tromethamine, respectively. Protect from freezing. Use only sterile needles, and use each needle only once. Lutalyse for goats can be effective in changing phase length and well as addressing "cystic" does and has been shown to help some does "reset" hormonally and resolve some fertility issues. Distributed by:Zoetis Inc.Kalamazoo, MI 49007 Controlling Time of Estrus of Estrous Cycling Mares: Mares treated with LUTALYSE Injection during diestrus (4 or more days after ovulation) will return to estrus within 2 to 4 days in most cases and ovulate 8 to 12 days after treatment. Cattle that abort will abort within 35 days of injection. Heart rate, respiration rate, rectal temperature, and sweating were measured at 0, 0.25, 0.50, 0.75, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, and 6.0 hr. The results indicated no treatment related effects from dinoprost treatment that were deleterious to the health of the animals or to their offspring. 2018 Pipestone Veterinary Services. Mares: For Difficult-to-Breed Mares: In one study with 122 Standardbred and Thoroughbred mares in clinical anestrus for an average of 58 days and treated during the breeding season, behavioral estrus was detected in 81 percent at an average time of 3.7 days after injection with 5 mg LUTALYSE Injection; ovulation occurred an average of 7.0 days after treatment.

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