It's important you understand this information because this substance may harm you. This Website requires your browser to be JavaScript enabled. Product Classification | Tunnel Dmagntiseurs Plans d'expansion futurs du march, demande par rgions jusqu'en 2030. Chemical Structure for 1,2,4-Trichlorobenzene. P264: Wash skin thoroughly after handling. . The product quantity has been adjusted. reaction search pages in place of the enumerated reaction Recently, polymerization of structure 102 carried out in 1,2-dichlorobenzene at 25 . Notice: This spectrum may be better viewed with a Javascript - 298. How can families reduce their risk for exposure to trichlorobenzenes? 1,2,4-trichlorobenzene The TCB/toluene solution of La@C82 (C2v) and an excess amount of Ad in a seal tube was irradiated with a high-pressure mercury lamp, producing the monoadduct in 80% yield. Selling Leads | (1,5) 1,2,4-Trichlorobenzene has an aromatic odor, with an odor threshold of 3 parts per million (ppm). Thermodynam., 1982, 14, 303-308. P264: Wash skin thoroughly after handling. CAS 120-82-1, chemical formula CH-1,2,4- (Cl). H302: Harmful if swallowed. Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 118 K) Not assessed under the IRIS Program. The general population may be exposed to trichlorobenzenes by inhaling air and through the ingestion of food and drinking water. CAS 120-82-1, chemical formula CH-1,2,4- (Cl). H302: Harmful if swallowed. In soil, 1,2,4-tribromo-3,5,6-trichlorobenzene is expected to be immobile based upon an estimated Koc of 9.3X10+4. [all data], Wilhelm, Inglese, et al., 1982 CHEMICAL NAME : Benzene, 1,2,4-trichloro- CAS REGISTRY NUMBER : 120-82-1 BEILSTEIN REFERENCE NO. [all data], Sears and Hopke, 1949 The Food and Drug Administration (FDA) has determined that the concentration of 1,2,4-trichlorobenzene in bottled drinking water should not exceed 0.07 mg/L. T = temperature (K). P = vapor pressure (bar) (TRC) data available from this site, much more physical Yan, H.; Gu, J.; An, X.; Hu, R., ; 1.) All rights reserved. A general reaction search Trichlorobenzenes do not have widespread use in consumer products that are readily available to the general public. Jones, A.H., There are no studies of children exposed to trichlorobenzenes. 2021 by the U.S. Secretary of Commerce [all data], Wilhelm, Lainez, et al., 1986 Mice given 1,2,4-trichlorobenzene in the food for 2 years developed cancer of the liver. Maintain clean baselines and improve chromatography run reproducibility with efficient filtration. Here, we systematically characterize th Chem. available from the NIST/EPA/NIH Mass Spectral Library. its accompanying search program. the Structure comprising metallized film and ethylene copolymer AT425217T (de) * 2005-05-12: 2009-03-15: Dow Global Technologies Inc: . Create the perfect solution - match and clear hexagones. Hydrophobic and volatile chemicals have proven to be difficult to dose in cell assays. and Informatics, NIST / TRC Web Thermo Tables, professional edition (thermophysical and thermochemical data), Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein. van de Lande, L.M.F., Polymeric Microspheres and Magnetic Beads, Novabiochem Peptide and DNA Synthesis Reagents, Analytics and Sample Preparation Services, BioReliance Cell and Gene Therapy Testing Services, Calibration, Verification and Suitability Testing, Process Solutions: Portfolio Announcements, Organic Synthesis Building Blocks and Reagents for Pharma. Chem. Articles of 1,2,4-Trichlorobenzene are included as well. Agency for Toxic Substance and Disease Registration. Advanced; SDS; Certificates; Chemical Structure This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. The purpose of the fee is to recover costs associated Is there a medical test to show whether I've been exposed to trichlorobenzenes? The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Th click the mouse on the plot to revert to the orginal display. Yan, H.; Gu, J.; An, X.; Hu, R.-H., AC - William E. Acree, Jr., James S. Chickos It is a derivative of benzene with three chloride substituents. 1,2,4-Trichlorobenzene is produced in large quantities and is used as a solvent to dissolve special materials such as oils, waxes, resins, greases, and rubber. Aside from its use as a solvent, this compound is a useful precursor to dye and pesticides. Chem. 2-Bromo-1,3,4-trichlorobenzene This substance exists as a Related Substance of the following substances. Copyright for NIST Standard Reference Data is governed by Spieksma, Walter; Luijk, Ronald; Govers, Harrie A.J., In addition to the Thermodynamics Research Center [all data], Schlosser, Marzi, et al., 2001 Some of the following links exit EPA's site Weight of Evidence for Cancer (PDF) (14 pp, 118 K) 1,2,4-Trichlorobenzene is produced in large quantities and is used as a solvent to dissolve special materials such as oils, waxes, resins, greases, and rubber. [4] There is no regulated occupational exposure limit for chemical exposure, but the National Institute for Occupational Safety and Health recommends no greater exposure than 5 ppm, over an 8-hour workday. Synonyms. Trichlorobenzenes have primarily been used as solvents and chemical intermediates to produce other compounds. Volatilization from moist soil surfaces may be an important fate process based upon an estimated Henry's Law . intended to imply recommendation or endorsement by the National You will be subject to the destination website's privacy policy when you follow the link. The acidity of chloro-substituted benzenes: A comparison of gas phase, ab initio, and kinetic data, CAS: 120-82-1 MDL: MFCD00000547 EINECS: 204-428- . Institute of Standards and Technology, nor is it intended to imply It is a colorless liquid used as a solvent for a variety of compounds and materials. H315: Causes skin irritation. The presence of trichlorobenzenes in your body does not necessarily mean that you will suffer adverse health effects. We are rebranding all of our life science products, labels, packages and documents. Russ. Chem., 1981, 85, 1490. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. [all data], van de Lande, 1932 There are no studies of cancer in people exposed to trichlorobenzenes. Ind. 1,2,4-Trichlorobenzene, Last Updated Date : Eng. L'tude de Tunnel Dmagntiseurs Le march comprend des statistiques sur la taille du march, les parts rgionales et les parts des concurrents, les segments profonds, les tendances du march, les opportunits et d'autres informations pertinentes. Shop 1,2,4-Trichlorobenzene (HPLC), Fisher Chemical at Fishersci.com. How likely are trichlorobenzenes to cause cancer? They help us to know which pages are the most and least popular and see how visitors move around the site. Cookies used to make website functionality more relevant to you. Converge, Intensify and Evolve. However, based on results from studies in animals, it is reasonable to predict that humans exposed to high amounts of trichlorobenzenes may develop liver problems. Catalog number: 157900025. The following list includes links related to the selected substance. Data, 1998, 43, 5, 770-775, https://doi.org/10.1021/je9701442 Journal of Chromatography A, 1994, 672, 1-2, 141-148, https://doi.org/10.1016/0021-9673(94)80602-0 Benzene, 1,2,4-trichloro-Trichlorobenzene; Trichlorobenzene, 1,2,4-Trojchlorobenzen; UN 2321; more synonyms . Hydrophobic and hydrophilic membranes for filtration and venting applications. d(ln(kH))/d(1/T) = Temperature dependence constant (K), Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, Data compiled as indicated in comments: TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director Standard enthalpies of formation and enthlpies of isomerization of trichlorobenzenes, Trichlorobenzenes have been identified in a variety of food items including vegetables, milk, eggs/meat, and oils produced from various nuts and seeds. the library and PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine 1,2,4-Trichlorobenzene is an organochlorine compound, one of three isomers of trichlorobenzene. Select a region with data to zoom. However, NIST makes no warranties to that effect, and NIST H410: Very toxic to aquatic life with long lasting effects. Not assessed under the IRIS Program. . Our portfolio of innovative products, services and solutions. Use or mention of technologies or programs in this web site is not Contact Us to ask a question, provide feedback or report a problem. 15, Am. It is mainly used as a precursor chemical in the synthesis of agrochemicals, as a preferred solvent for dissolving and . in these sites and their terms of usage. Recommended vapour and sublimation pressures and related thermal data for chlorobenzenes, It is a derivative of benzene with three chloride substituents. Vapor Pressures of the Isomeric Trichlorobenzenes in the Low Pressure Region, The interactive spectrum display requires a browser with JavaScript and The half-life (the time it takes for 50% of the compound to degrade) of trichlorobenzenes in air is about 1 month. 1,2,4-Trichlorobenzene is a highly chlorinated aromatic solvent. Chem. The chemical formula for 1,2,4-trichlorobenzene is C 6 H 3 Cl 3, and its molecular weight is 181.46 g/mol. Chim. Email: Contact CDC-INFO. 4770 Buford Highway Ruscic, B.; Klasinc, L.; Wolf, A.; Knop, J.V., Physical description. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. ATSDR can also tell you the location of occupational and environmental health clinics. ; Simulin, Yu.N., [all data], Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References. [all data], Platonov and Simulin, 1985 We take your privacy seriously. by the U.S. Secretary of Commerce on behalf of the U.S.A. The presence of trichlorobenzenes in your body means that you have been exposed to trichlorobenzenes. Explore, interact. : Washington, D. C., 1955. Follow the links above to find out more about the data Depending on the conditions and additives (e.g., sulfur), it can be the main product from the chlorination of benzene. Therefore, it is diamagnetic. Follow the links above to find out more about the data been selected on the basis of sound scientific judgment. Trichlorobenzenes tend to evaporate from water, but can also bind to suspended solids and sediment in water. The preparation method of any one of Claims 1 to 9, wherein, the first solvent is selected from one or a mixture of two or more of 1,2,4-trichlorobenzene, o-dichlorobenzene, chlorobenzene, anisole, toluene, nitrobenzene, isopropyl alcohol, These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. The EPA has determined that exposure to 1,2,4-trichlorobenzene or 1,3,5-trichlorobenzene in drinking water at concentrations up to 0.1 and 0.6 milligrams per liter (mg/L), respectively, for 1 or 10 days is not expected to cause any adverse effects in a child. Our customer service and technical service organizations are dedicated to you, our customer. There is virtually no information regarding health effects of trichlorobenzenes in humans. H315: Causes skin irritation. All rights reserved. Soc., 1949, 71, 7, 2575-2576, https://doi.org/10.1021/ja01175a094 "hFzhkids={S:'.[6Sb:)KUQrFOsaNGfOD3!O-9CqKlT@ HQAW Ks-vWT>NyOKV"}=^8&,%+ Composition(s) generated upon use Other types of composition(s) Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The . J. Chem. Wilhelm, E.; Inglese, A.; Quint, J.R.; Grolier, J.-P.E., uses its best efforts to deliver a high quality copy of the Pays-Bas, 1932, 51, 98-113. unsym-trichlorobenzene; 1,2,4-trichlorobenzol. Physical Properties. 1,2,4-Trichlorobenzene is an organochlorine compound, one of three isomers of trichlorobenzene. Soc. Browse 1,2,4-Trichlorobenzene and related products . HTMO1WHCH=bJT;q&a2v=|W~^b6Lmr"{OL{yP7?Nk.TTA(#` FxS*Ah,YjjKSTF9x:q0ffvn 0htoh D"od,,76=:(x Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org Spin-coating has been used extensively in the fabrication of electronic devices; however, the effects of the processing parameters have not been fully explored. Promotional price valid on web orders only. Price (EUR) Price: 98,60. Trichlorobenzene (TCB) may refer to any of three isomeric chlorinated derivatives of benzene with the molecular formula C6H3Cl3. Toggle navigation. High levels of trichlorobenzenes are often detected in fish or other species living in contaminated waters because trichlorobenzenes can accumulate in fatty tissues. How can trichlorobenzenes affect children? [all data], Dreisbach, 1955 This page allows searching for GPC of polyolefines such as PE or PP which are otherwise insoluble. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. (1) The vapor pressure for 1,2,4-trichlorobenzene . Sublimation Pressure Data for Organic Compounds., J., 2001, 7, 16, 3511-3516, https://doi.org/10.1002/1521-3765(20010817)7:16<3511::AID-CHEM3511>3.0.CO;2-U been selected on the basis of sound scientific judgment. MSDS/SDS Database Search | The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. . Vapor Pressure of Pure Substances. NOAEL : 1.48 x 10 1. mg/kg-day. These cookies may also be used for advertising purposes by these third parties. Trav. III. Synonyms. (Engl. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Stable. Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 118 K) gas phase; Acid: 1,2,4-trichlorobenzene. Data compilation copyright The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. the Primary and secondary antibodies, blockers and custom services. unsym-trichlorobenzene; 1,2,4-trichlorobenzol. All mass spectra in this site (plus many more) are Biologically Active Compounds | Chem. Rohc, Vladislav; Ruzicka, Vlastimil; Ruzicka, Kvetoslav; Aim, Karel, Petit, J.C.; TerMinassian, L., HeH + contains all paired electrons. All Rights Reserved. Formula. Anion assigned based on ab initio calculations. This fact sheet is one in a series of summaries about hazardous substances and their health effects. Greater control & increased flexibility for both small & large molecule development & manufacturing processes. Shanghai Jizhi Biochemical Technology Co., Ltd, 1,2,4-Trichlorobenzene suppliers in China, 5-(4-Chlorophenoxy)-1,2,4-trichlorobenzene, 5-((4-Chlorophenyl)sulfinyl)-1,2,4-trichlorobenzene, 1,2,4-tris(methylthio)-3,5,6-trichlorobenzene. errors or omissions in the Database. spectrum (can be printed in landscape orientation). CRC Handbook of Data on Organic Compounds, 2nd Editon, Weast,R.C and Grasselli, J.G., ed(s)., CRC Press, Inc., Boca Raton, FL, 1989, 1. Journals | Watch, learn and engage with us. Good cell culture practices start with proven products like Stericup and Millex filters. 238,252,276,284-286 The lower viscosity of the reaction mixture allowed for the better control of the process. InChI=1S/C6H3Cl3/c7-4-1-2-5(8)6(9)3-4/h1-3H, National Institute of Standards and The 1,2,4-trichlorobenzene calibration gas was streamed from the reservoir toward the PTR-TOF-MS inlet system and regulated with a steel needle valve to produce well-defined peaks in the mass spectrum, of 1000 cps (counts per second). A-006. following TRC products: Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes. It is virtually the exclusive product from the chlorination of 1,4-dichlorobenzene. Please see the following for information about Buying Leads | Studies in animals indicate that oral administration of trichlorobenzenes for short or long periods produces mainly alterations in the liver and kidneys. Benzene, 1,2,4-trichloro- Formula: C 6 H 3 Cl 3 Molecular weight: 181.447 IUPAC Standard InChI: InChI=1S/C6H3Cl3/c7-4-1-2-5 (8)6 (9)3-4/h1-3H IUPAC Standard InChIKey: PBKONEOXTCPAFI-UHFFFAOYSA-N CAS Registry Number: 120-82-1 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file NIST subscription sites provide data under the Here, the parent ring is styrene a benzene ring is attached to the vinyl unsaturated protons, and the chloro group is present . with the development of data collections included in Even though the forms have the same molecular weight and molecular formulae, they are structurally different by the positions of the chlorine atoms attached to the benzene ring. Enter the desired X axis range Anion assigned based on ab initio calculations. Data compiled by: Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein, Go To: Top, Gas phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, Data compiled as indicated in comments: The lower energy states of HeH + is reached when product formed are He + H +.. QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES. InChI=1S/C6H3Cl3/c7-4-1-2-5(8)6(9)3-4/h1-3H, National Institute of Standards and Physical Properties of Chemical Compounds, Advances in Chemistry Series No. It is mainly used as intermediate in dyes, pesticides and also as a lubricant. 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, but 1,2,4-trichlorobenzene is a colorless oil. A dermal exposure study in mice was found inadequate for drawing conclusions as to carcinogenicity in humans. NIST Standard Reference shall not be liable for any damage that may result from You will need Adobe Reader to view some of the files on this page. The bar impact test facilities include Hopkinson bar [1,2], split Hopkinson bar (Kolsky bar) [3,4,5,6,7,8,9,10], and direct impact Hopkinson bar [11,12,13].Schematics of the impact systems are illustrated in Figure 1.The Hopkinson bar measures blast/impact waves that enter through the end surface of the bar. Data, 1960, 5, 2, 196-200, https://doi.org/10.1021/je60006a019 PTFE filter & XAD-2 (100/50 mg) [SKC 225-17A & SKC 226-30-4]. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. ; Hopke, E.R., : 0956819 LAST UPDATED : 199712 DATA ITEMS CITED : 31 MOLECULAR FORMULA : C6-H3-Cl3 MOLECULAR WEIGHT : 181.44 WISWESSER LINE NOTATION : GR BG DG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : errors or omissions in the Database. Long term administration of 1,2,4-trichlorobenzene to rats did not affect their capacity to have normal offspring. [all data], Rohc, Ruzicka, et al., 1998 Trichlorobenzenes can be measured in blood and body fat, but the tests used are not routinely available in the doctor's office. C6H3-1,2,4-(Cl)3. Copyright for NIST Standard Reference Data is governed by What Generation is Your Sterility Testing Pump? LLK - Sharon G. Lias, Rhoda D. Levin, and Sherif A. Kafafi, Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, Data compiled by: Tanya L. Myers, Russell G. Tonkyn, Ashley M. Oeck, Tyler O. Danby, John S. Loring, Matthew S. Taubman, Stephen W. Sharpe, Jerome C. Birnbaum, and Timothy J. Johnson, Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director, Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, UV/Visible spectrum, References, Notes. Medium. Your contract pricing may differ. HeH + has bond order 1.. [all data], Ruscic, Klasinc, et al., 1981 ), 1985, 59, 179-181. Cosolvents are often needed to dissolve these chemicals in cell culture medium. 2023 Merck KGaA, Darmstadt, Germany and/or its affiliates. 1,2,4-Trichlorobenzene anhydrous, 99% Synonym (s): 1,2,4-TCB Empirical Formula (Hill Notation): C6H3Cl3 CAS Number: 120-82-1 Molecular Weight: 181.45 Beilstein: 956819 EC Number: 204-428- MDL number: MFCD00000547 PubChem Substance ID: 57648386 NACRES: NA.21 Pricing and availability is not currently available. [all data], Spieksma, Luijk, et al., 1994 Determination of the liquid vapour pressure of low-volatility compounds from the Kovts retention index, ALS - Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein Select a region with no data or Your institution may already be a subscriber. 1,2,4-Trichlorobenzene for synthesis. However, a study in rats given 1,2,4- or 1,3,5-trichlorobenzene found lesions in the eyes of the pups. Contact Us to ask a question, provide feedback, or report a problem. Disclaimer, Copyright 2023 ChemSrc All Rights Reserved. Fast, safe transfer of plates to isolator. The standard enthalpies of formation of mono-1,2,4- and 1,3,5-tri-, and 1,2,3,4- and 1,2,3,5-tetrachlorobenzenes, Properties Grade anhydrous Colorless liquid or crystalline solid (below 63F) with an aromatic odor. Wilhelm, E.; Lainez, A.; Roux, A.H.; Grolier, J.-P.E., To view more metadata about the specific Synonym, click on the Synonym. Standard Reference Data Act. How might I be exposed to trichlorobenzenes? NIST Standard Reference 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, while 1,2,4 trichlorobenzene is a colorless liquid. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Am. (5) 1,2,4-Trichlorobenzene occurs as a colorless liquid that is insoluble in water. Select search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources Sears, G.W. and HTML 5 enabled browser. Trust in one of the most highly published & validated portfolios of antibodies. gas phase; Acid: 1,2,4-trichlorobenzene. B - John E. Bartmess Res. ; Coefficents calculated by NIST from author's data. Dreisbach, R.R., We are the partner of choice for water purification systems and services. There is almost no information about health effects of trichlorobenzenes in humans. in these sites and their terms of usage. Trichlorobenzenes have primarily been used as solvents and chemical intermediates to produce other compounds. Trichlorobenzenes are volatile and preferentially enter the air when released to the environment. J. Chem. It is not known whether trichlorobenzenes could affect reproduction in humans.

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